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KMID : 0363420170310030014
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Journal of Korean Oriental Pediatrics
2017 Volume.31 No. 3 p.14 ~ p.23
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Effect of Skin Fat Lipid Barrier Formation on Hataedock with Coptis Japonica & Glycyrrhiza Uralensis
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Ahn Sang-Hyun
Kim Ki-Bong
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Abstract
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Objectives: This study is conducted to evaluate skin fat barrier formation of Hataedock using the Coptis japonica & Glycyrrhiza uralensis extract.
Methods : The 3-week-old NC/Nga mice were divided into 3 groups: control group (Ctrl), Hataedock-treated group that uses the Coptis japonica & Glycyrrhiza uralensis (CGT) extract, and Hataedock-treated group that uses Bifidobacterium
(BBT). After 2 weeks, changes in immunohistochemicals, and skin-lipid-barrier regulators were observed for the
effects of Hataedock.
Results : In CGT group, loricrin-positive reaction has been increased by 231%, along with involucrin-positive reaction by
90%, filaggrin-positive reaction by 143%, and ASM-positive reaction by 341% in the stratum corneum.
Conclusions: Hataedock, using the extract of Coptis japonica & Glycyrrhiza uralensis, increased the expression of proteins promoting keratinocyte differentiation. This leads into conclusion that Hataedock may increase the keratinocyte
formation and function which promotes skin barrier formation.
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KEYWORD
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Hataedock, Filaggrin, Loricrin, Involucrin, Skin
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